“ESMS, a spin-out from Guy’s Hospital Poisons Unit, provides a unique service to clinical trials which goes beyond a simple unblinding service of the type that an NHS on-call pharmacist might provide. This service is designed to prevent inappropriate unblinding as in most cases, the A&E doctor is confident to proceed with the patient’s treatment without unblinding, thus improving patient retention and reducing the need for higher patient recruitment. Retaining patients on the study is also crucial to the success of the grant.”